Onde Comprar o livro Blood Substitutes: Physiological Basis Of Efficacy – Winslow, Robert W. – ISBN: 0817638040. Veja em loja online o preço deste livro.
‘This book is very neatly produced…[will be] useful to those working in blood substitution research.’ – Polymer Division News, October 1996 ‘This book is a good reference for all those who are interested in physiology of circulatory system and the researchers and technologists who are interested in synthetic substitutes for biomaterials.’ – Journal of Cytology and Genetics ‘Overall, this volume offers a concise and state-of-the-art overview of the subject, ans as such the medical practitioner, hematologic specialist, and investigator in blood substitutes will find it useful.’ – The Quarterly Review of Biology, June 1996 The development of a substitute for transfused red blood cells is a highly sought-after goal. Such products potentially would be safer than human (allogeneic) blood because they would eliminate the possibility of transmitting infectious agents such as HIV. In addition, red cell substitutes will revolutionize the practice of transfusion medicine: they will eliminate the need for cross-matching, and could lead to an overhaul of current blood bank operations because they may be more stable and thus easier to store than blood. Before reaching this ambitious goal, the fundamental obstacle appears to be a lack of understanding of the way in which cell-free oxygen carriers transport oxygen, with consequent implications for clinical trials and eventual approval of new products. This volume is a collection of essays by outstanding authorities in a wide range of fields. Each chapter focuses on the problem of red cell substitutes from a different perspective. The discussion in the first chapter of the world-wide impact that blood substitute products would have is of particular interest and importance. All in all, this collection elucidates the current status of red cell substitute research and development in a unique and timely manner. Contents: Foreword Preface 1. Transfusion Alternatives: Impact on Blood Banking Worldwide, Peter Tomasulo 2. Demonstration of the Efficacy of a Therapeutic Agent, Joseph Fratantoni 3. A Physiologic Basis for the Transfusion Trigger Combat Casualties, Robert M. Winslow 4. Blood and Red Blood Cell Substitutes: A Military Perspective, Jon C. Bowersox and John R. Hess 5. Clinical Development of Perfluorocarbon-based Emulsions as Red Cell Substitutes, Robert J. Kaufman 6. Design of Chemically Modified and Recombinant Hemoglobins as Potential Red Cell Substitutes, James M. Manning 7. Encapsulation of Hemoglobin in Liposomes, Alan S. Rudolph 8. Stability and Toxicity of Hemoglobin Solutions, Kim D. Vandegriff 9. Red Cell Substitutes in the Kidney, Roland C. Blantz, Andrew P. Evan, and Francis B. Gabbai 10. A Theoretical Analysis of Oxygen Transport: A New Strategy for the Design of Hemoglobin-based Red Cell Substitutes, Kim D. Vandegriff and Robert M. Winslow 11. Microcirculatory Consequences of Blood Substitution with aa-Hemoglobin, Amy G. Tsai, Heinz Kerger, and Marcos Intaglietta 12. Oxygen Delivery Regulation: Implications for Blood Substitutes, Paul C. Johnson, Keith Richmond, Ross D. Shonat, Andreas Toth, Mihlos Pal, Marc E. Tischler, and Ronald M. Lynch 13. Tumor Oxygenation and Radiosensitivity, Herman Suit Index
Autor: Winslow, Robert W.