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This volume explores the basic physiological functions of granulocytes, their modification by cytokines, and the clinical experience with cytokines – discussing the specific responses of neutrophils, eosinophils, basophils, and mast cells to individual cytokines. Written by more than 60 experts from all over the world, Granulocyte Responses to Cytokines – examines the responses of granulocytes and mast cells to hormones, chemotactic peptides, and phorbol esters; details cytokine effects on morphology, micration, adhesion, phagocytosis, degranulation, and cytotoxicity against tumour cells and pathogens; covers cyclic nucleotide, protein kinases, G proteins, lipoxygenase, and leukotrienes in the regulation of granulocyte functions; indicates caution in the use of cytokine therapy for certain leukaemias due to cytokine effects on the growth of malignant cells; and presents clinical studies with granulocyte-macrophage and granulocyte colony-stimulating factors with promising results in treating genetic, virus-, and drug-induced granulocytopenias and immunodeficiencies.
Autor: Coffey, Ronald G.