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Model organisms are becoming increasingly useful in a systematic approach to a broad array of disease-based questions. With the advanced genetic techniques that are available for the model organisms and the availability of their genome sequences, these organisms are poised to have a major impact in drug discovery, particularly in the critical area of protein target validation. This book details recent advances in bioinformatics, proteomics, genomics, biochemical and automation technologies as applied to simple organisms in an integrated drug discovery platform.