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A survey of recent research on neurotoxicology and the impact of endogenously synthesized neurotoxins on normal and pathophysiological regulation in the central nervous system, written for researchers, neuropharmacologists, biochemists, and neurotoxicologists. The 12 contributions are divided into two parts. The first deals with the chemical and biochemical aspects of the origin, formation, and degradation of tetrahydroisoquinolines and other compounds and the sceond covers physiological, biochemical, and neuropharmacological aspects of various enzymes.