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As part of the Annals of the New York Academy of Sciences series, this volume examines mechanisms involved in bone development and restructuring, including cellular and mechanical triggers, receptors, and signalling pathways. This volume also examines other factors associated with bone and musculoskeletal health, including physiological systems and disease states such as the immune system, inflammation, diabetes, infection and cancer. This book is ideal for Graduate students, medical students, researchers and clinicians in with an interest in anatomy, physiology, developmental biology, immunology, and musculoskeletal health NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.