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Steroid hormones influence nearly every major physiological process. The actions of these hormones are mediated by their initial interaction with intracellular receptor proteins. Steroid receptors, along with other members of the steroid receptor superfamily, act as transcriptional factors to influence gene expression in target cells. Recent studies indicate that the presence of functionally active steroid receptors in malignant tissues could positively influence endocrine treatment of many cancers. This book contains state-of-the-art reviews contributed by leading investigators in the general area of molecular mechanisms of steroid hormone action. All chapters are uniformly written and easy to comprehend. Students, established investigators, and those entering the field with an interest in the basic and clinical aspects of steroid hormones will find this volume indispensable. Series: Hormones in Health and Disease, Editor: V.K. Moudgil Contents Preface List of Contributers Part I – Introduction 1. Steroid/Nuclear Receptor Superfamily: recent Advances and Relation to Health and Disease, V.K. Moudgil Part II – Steroid Receptor Interactions with DNA and Nuclear Components 2. Structural and Functional Studies of Selective DNA Binding by Steroid/Nuclear Receptors, Leonard P. Freedman, Ben F. Luisi, Iris Alroy, and Terri L. Towers 3. Estrogen Receptor Induced DNA Bending, David J. Shapiro, Geoffrey, L. Greene, and Ann M. Nardulli 4. The Nuclear Environment and Estrogen Action, Jerry R. Malayer and Jack Gorski 5. Functional Interaction of the Estrongen Receptor with the Tissue-Specific, Homeodomain Transcription factor, PIT-1, Richard A. Maurer, Richard N. Day, Yasuhiko Okimura, and Barbara E. Nowakowski 6. Insights into the Genomic Mechanism of Action of 1,25-Dihydroxyvitamin D3, J. Wesley Pike 7. Molecular Mechanisms of Thyroid Hormone and Retinoic Acid Action, Magnus Pfahl Part III – Receptor Structure and Associated Proteins 8. Heat Shock Proteins and the Cytoplasmic-Nuclear Trafficing of Steroid Receptors, William B. Pratt and Lawrence C. Scherre 9. In Vitro Assembly of the Avian Progesterone Receptor, David F. Smith, William P. Sullivan, Jill Johnson, and David O. Toft 10. Steroid Receptor Associated Proteins: Heat Shock Protein 90 and P59 Immunophilin, Marie-Claire Lebeau, Nadine Binart, Francoise Cadepond, Maria-Grazia Catelli, Beatrice Chambraud, Nelly Massol, Christine Radanyi, Gerard Redeuilh, Jack-Michel Renoir, Michele Sabbah, Ghislaine Schweizer-Groyer, and Etienne-Emile Baulieu 11. Estrogenic and Developmental Regulation of 90-Kilodalton Heat Shock Protein Gene Expression, G. Shyamala Part IV – Receptor Modification and Hormone/Antihormone Interactions 12. Phosphorylation and Progesterone Receptor Function, Nancy L. Weigel, Angelo Poletti, Candace A. Beck, Dean P. Edwards, Timothy H. Carter, and Larry A. Denner 13. Estrogen Receptor Activation by Ligand-Independant Pathways, Carolyn L. Smith, Orla M. Conneely, and Bert W. O’Malley 14. Why are Steroid Receptor Antagonists Sometimes Antagonists? Kathryn B. Horwitz and Kimberly K. Leslie 15. Ligand Requirments for Estrogen Receptor Function and the Actions of Antiestrogens, Joseph C. Reese and Benita S. Katzenellenbogen Part V – Steroid Receptors and Clinical Correlations 16. Molecular Biological Aspects of the Human Androgen Receptor Relating to Disease, Zhong-xun Zhou, Madhabananda Sar, Frank S. French, and Elizabeth M. Wilson 17. Estrogen Receptor Variants in Breast Cancer, Carlos A. Encarnacion and Suzanne A.W. Fuqua Part VI – Emerging and Novel Systems 18. Human Bone Cells: Newly Discovered Target Cells For Sex Steroids, Thomas C. Spellsberg, Merry Jo Oursler, James P. Landers, Malayannam Subramaniam, Steven A. Harris, and B. Lawrence Riggs 19. Characteristics of the Human Estrogen Receptor Protein Produced in Microbial Expression Systems, James L. Wittliff, Jing Dong, Christine Schaupp, Petr Folk, and Tauseef Butt 20. The Ah Locus: A Review, Alan Poland and Chris Bradfield Author Index Subject Index
Autor: Moudgil, V.k.