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A comprehensive review of pharmacologic treatments for metabolic bone disease. The authors discuss the clinical pharmacology and practical aspects, including dose, frequency and route of administration, side effects and monitoring of a variety of drug treatments as they are applied to conditions such as hypoparathyroidism, Paget’s disease and osteoporosis. Cost and advantages and disadvantages of the various preparations are also discussed in full, and an indication of the drug of first choice is given.